Stoichiometry of Type I R-M enzymes
HsdM and HsdS are able to produce an independent
methylase (MTase) of stoichiometry M2S1. The fully active holoenzyme has a stoichiometry of R2M2S, but the subassembly complex (R1-complex lacks one of the HsdR subunits thus preventing restriction activity. Drexler’s Molecular Assembler
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